Health-e-Iron LLC, is an affiliate of Iron Disorders Institute (IDI) and the Hemochromatosis Foundation. Together, our affiliation comprises the largest iron-health public interest organization in the world. We are now offering direct-to-consumer blood tests in 41 participating states. This service is provided through a partnership with Direct Laboratory Services (DirectLabs). Tests can be ordered and purchased online. The test order will be authorized by a DirectLabs physician licensed in your state.
Health-e-Iron Risk Analysis Algorithm
Directly below is a graphic of our Risk Analysis Table that covers the primary biochemical measures scored according to our risk assessment tool, FeGGT LifePro™. This science-based special test panel measures both your iron status and the adequacy of your antioxidant defense system. You can read and see more about this tool and how it works on our on our About FeGGT LifePro™ page. There you also will find charts, summary descriptions and graphics that are derived or adapted from more than 500 scientific studies stored on this site's Science Library pages. A sample risk matrix based on the blood test results portion of our FeGGT LifePro™ Health Risk Calculations section appears below:
Health-e-Iron note: the above model represents the blood test component of our risk algorithm for adult men. Models adjusted to gender and menopausal status are available on our our Health Risk Calculator section. We recommend visiting our Who Should be Tested page first to see how our risk scoring system works.
A Few Examples of Tables and Charts from our Science Libraries
The below example was derived from one of more than 100 studies focused on elevated Gamma Glutamyl Transferase (GGT), as a factor in health and mortality risk. You will find many similar Relative Risk matrices throughout the Science Library pages of our web site. This table is based on the results reported in article #2 on our GGT-Heart page.
The below chart is an example from study #13 on our GGT-Diabetes page. Note that GGT is a significantly more powerful in predicting new cases of diabetes than obesity alone, even when BMI is above 30 or 35. Note also that elevated GGT increases the risk of diabetes in normal weight people by 3 fold.
Fig. 1. Adjusted odds ratios (ORs) and 95% CIs of newly recognized diabetes (205 cases) by category of BMI and quartiles (Q) of serum GGT. Numbers in the table are the numbers of cases and individuals at risk in each category. ORs were adjusted for age, sex, race/ethnicity, poverty income ratio, cigarette smoking, leisure time physical activity, and alcohol consumption; all ORs were calculated with the reference group of subjects with lowest category of both BMI and serum GGT. First and 2nd quartiles of serum GGT were combined because of small numbers of cases of newly recognized diabetes.
The following chart is an example from study #10 on our GGT-Heart page. Note that in this large population study from Austria, elevated GGT, even when well-within the "normal" range, was associated with significant premature mortality risk across all of the leading causes of death. In this large study of 283,438 men and women (median age 50 yrs.) only 37% of the study population had baseline GGT in the lowest risk category. Also consider that life expectancy in Austria is two years longer than in the U.S. Studies preformed in the U.S. indicate that only about 25 to 30% of the U.S. adult population has GGT in the lowest risk category.
Fig. 3.Adjusted mortality among patients according to subgroups of GGT. GGT was classified as described in Materials and Methods. The lowest category (<9 U/L in women and <14 U/L in men) served as reference category.
Health-e-Iron note: we have prepared an analysis using the data from the above study based upon the distribution of deaths attributed to elevated GGT in Austria. The resulting distribution was then incorporated into an analysis of the current U.S. population at risk and the established 2009 mortality rates for men and women between ages 30 and 70 years. The take-home point of this analysis is that in the U.S. more than 750 premature deaths per day could be attributable to elevated GGT. We believe this analysis is somewhat conservative since life expectancy is longer and mean GGT levels are lower in the Austria compared to comparably-aged individuals in the U.S. The complete analysis can be viewed by clicking this LINK. We welcome comments or critiques by correspondence using our Contact Us page.
The following example is a chart from study #5 on our IRON-Heart page. In this study of 826 men living in Austria, "serum ferritin was one the strongest risk predictors of overall progression of atherosclerosis." Note that the serum ferritin levels of Austrian men are significantly lower than those of American men. And as noted above, Austrian men enjoy an average two-year life expectancy advantage over American men.
Figure 1. Crude and regression-standardized risks of incident atherosclerosis (1990 to 1995) according to ferritin quintiles.
Health-e-Iron note: many other similar tables and graphs are located on our Science Library pages and in our Health Risk Calculator section.
Purchasing our Tests? This is How it Works
You can place an order through us at our DirectLabs web page. Either of our FeGGT LifePro™ (Basic or Premier) will supply the biochemical information needed to calculate your risk score. Simply select the tests or test panels you would like to order. Once you've purchased the tests, you will receive a physician-approved voucher by email. You can then go to a conveniently located patient service center in or near your community and provide a blood sample drawn by a licensed phlebotomist. The sample will be analyzed by a large CLIA approved laboratory. Test results will be delivered privately, securely and directly to you, the ordering physician, DirectLabs and Health-e-Iron.
Health-e-Iron and Iron Disorders Institute have recently designed a proprietary test panel called FeGGT LifePro™. This unique panel includes all of the measures required to calculate your body's iron levels plus a test for serum gamma glutamyltransferase (GGT). Over the last decade, GGT has proved to be an accurate measure of the body's natural antioxidant status. Excess iron stored in your body can be dangerous by itself; but when it's accompanied by weakened antioxidant defenses, disease consequences and even premature death occur far more frequently than when those measures are in healthy balance.
Health-e-Iron will inform any patients whose test results indicate an apparent iron imbalance and/or antioxidant deficiency, including conditions such as iron overload, suspected Hereditary Hemochromatosis or iron deficiency. Test analysis will be in accordance with Iron Disorder Institute's reference ranges established by its 22-member Medical and Scientific Advisory Board. We strongly encourage you to review the scientific literature that is contained on this website and through the links we've provided to the U. S. National Library of Medicine and other reliable resources.
Unfortunately, most physicians are not yet familiar with the recent scientific advances in this important area of health. Check your own history of lab tests first to see if you have had these tests in the past. Unless you have been previously diagnosed with an iron-related condition or a liver disease, it is not likely that your physician would have ordered these tests for you. Until now, risk markers of iron and antioxidant imbalances have been poorly understood and are seldom ordered by physicians in the course of regular check-ups. This has led to widespread under diagnosis or misdiagnosis of critical early disease markers, and an absence of guidance and treatment for most people facing the health risks that an accurate interpretation of these measures can demonstrate.
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