Anadrol Reviews, Results, Benefits & Side Effects

By Merrick Beslear | Bodybuilding

Sep 03

Oxymetholone, better known by its trade name Anadrol, gives excellent results in weight gain and power gain. However, it is also one of the most toxic anabolic steroids and the only one that has been scientifically proven to lead to liver cancer.

Because of the explosive burst of force, it increases the risk of muscle or tendon rupture during exercise. You cannot drink any alcohol when taking Anadrol because the combination of the two is liver-insoluble. Overall, Anadrol is a steroid which possesses a lot of risks for your health.

It is absolutely illegal in the majority of countries worldwide but you can actually get an alternative which gives similar results – Anadrole. This is the only legal option if you wish to try this steroid.

Anadrol Review & Results


What is Anadrol? Science of Anadrol:

Oxymetholone (Anadrol) is a powerful oral anabolic steroid derived from dihydrotestosterone. In particular, it is close to methyl dihydrotestosterone (mestanolone), differing only from the addition of a 2-hydroxy methylene group.

This creates a steroid with significantly different activity than mestanolone, so it is very difficult to compare between the two anabolic steroids. As mentioned in the beginning, oxymetholone is a very powerful anabolic hormone.

Dihydrotestosterone and Mestanolone are very weak in this regard due to the fact that the molecules of anabolic steroids are relatively unstable in the enzyme-rich medium of muscle tissue (3-alpha-hydroxysteroid dehydrogenase).

Many consider Anadrol to be the most potent steroid on the market. Beginners in steroid use experiment with this anabolic steroid and often the results show a 9 – 13kg increase in muscle mass when using the steroid for a period of 6 weeks.

Oxymetholone causes a great deal of water retention, so much of the weight gain is due to water. This effect often creates the feeling and confidence in the athlete that he or she is bigger and stronger while taking this anabolic steroid. Despite its well-rounded appearance, this anabolic steroid does relatively little to gain more power.

This gives it more elasticity and reduces the possibility of heavy lifting injuries. However, we should note that very rapid weight gain can also cause too much stress on connective tissue.

History of Anadrol


Anadrol was first described in 1959. This anabolic steroid was marketed in the United States as a drug in the early ‘60s under the trade names Anadrol-50 (Syntex) and Androyd (Parke Davis & Co.). Syntex developed this anabolic steroid and held the patent rights until their expiration years later.

Originally, they approved the drug for use in conditions requiring anabolic action. It was prescribed for elderly weight loss, chronic underweight, pre and post-operative muscle retention, recovery from infections, gastrointestinal diseases, osteoporosis, and general catabolic conditions.

Despite its great potential for therapeutic use and its highly anabolic activity, the FDA is soon limiting the use of Oxymetholone. Until the mid-1970s, the FDA allowed it only for the treatment of anemia, which is characterized by insufficient production of red blood cells.

It is true that stimulation of Erythropoiesis is characteristic of almost all anabolic steroids that tend to increase red blood cell concentration. However, oxymetholone appears to be quite reliable in this regard, showing an increase in erythropoietin levels of as much as 5 units.

In July 1997, Syntex sold all rights to Anadrol-50 in the United States, Canada, and Mexico to Unimed Pharmaceuticals. Unimed reintroduces Anadrol-50 to the US market in 1998, this time targeting HIV/AIDS patients.

Patients with HIV usually suffer from anemia. This is often caused by the disease itself, opportunistic infections or antiretroviral medicines. They use Anadrol to combat the disease. Anemia in HIV patients is usually categorized as a disorder in the production of bone marrow red blood cells. The FDA approves the use of Oxymetholone for this particular disease.

Is Anadrol Legal Now?

In April 2006, Solvay Pharmaceuticals (the parent company of Unimed) sells the rights to Anadrol-50 to Alaven Pharmaceutical, LLC. Alaven continues to distribute Anadrol (Anadrol) to the United States pharmacy market but has not announced any other goals for its continued studies with Oxymetholone. Today, people continue to distribute Anadrol outside the United States, although in smaller and less regulated markets.

In fact, Oxymetholone is only available in the pharmaceutical market in certain countries. The composition and dosage may vary by country and manufacturer. Most brands contain 50mg oral tablets in packages of 100.

Benefits & Effects of Anadrol

Anadrol intake is associated with a dramatic increase in muscle weight in a short time (within the first 2-3 weeks of use), as well as a significant increase in strength. Athletes say that the effect reduces after the first 3 weeks, so it makes no sense to use Anadrol for more than 4-6 weeks.

It gives primarily quantity rather than quality and is well suited for off-road training. As it saturates the receptors quickly, weight gain drops rapidly after ingestion. When this happens, you have two choices: increase the dose (which, as you will see, is not desirable), or you should switch to a different product.

Of course, the side effects of taking this steroid are no joke. However, you can easily control them to some extent by the use of a moderate dose of 50-100 mg. daily and maintaining intake for no longer than 4-6 weeks.

However, the drop in weight and strength is very fast and abrupt – after a short period of time, you will look as you were before taking it. Anadrol is not a steroid for beginners. Only bodybuilders who are at a certain level of development should take it.

Once you stop using it, your normal body functions will return within a few months.

Side Effects of Anadrol

Anadrol may be the strongest steroid but unfortunately, it also has the most side effects.

You should follow the recommended dosages. Higher doses increase the risk of nausea, vomiting, loss of appetite, diarrhea, and sleep problems. Over-excitement may occur within the first few days until the body becomes accustomed to the drug.

Other side effects (besides aromatizing and gynecomastia) include blood clotting, yellowing of the skin and a change in mood. Basically, your strength grows, but your mood does not improve and you become aggressive.

In pre-pubertal adolescents, it can increase the penis size and cause more frequent erections. Baldness and acne occur in men after puberty, tenderness or swelling in the breast, painful erection, urinary problems, and hepatitis.

It is not recommended for women as it causes irreversible changes such as acne, voice fatigue, clitoral hypertrophy, and hoarseness, the hair on the legs and beard, menstrual disorders, and many more.

As already mentioned, Anadrol is the only anabolic androgenic steroid known to truly cause liver cancer.

Other well researched and proven side effects include:

  • Estrogenic

Oxymetholone (Anadrol) is an extremely estrogenic steroid. Gynecomastia is a common problem during intake and can be caused quite early in the cycle (especially when you take higher doses).

At the same time, water retention can become a problem, causing a remarkable loss of muscle definition caused by both subcutaneous water and fat retention.

To avoid severe estrogenic side effects, the use of anti-estrogens such as Nolvadex or Clomid may be necessary. It is important to note that oxymetholone does not convert directly to estrogen in the body.

  • Androgenic

Although Oxymetholone is classified as an anabolic steroid, the occurrence of androgenic side effects is possible. They can be expressed in oily skin, acne, facial and body hair. Anabolic/androgenic steroids can also cause male pattern baldness.

Women should be aware of potential virilizing effects. Such include thickening of the voice, menstrual disorders, and changes in the structure of the skin. Lastly, you can experience changes in facial hair, and enlargement of the clitoris.

  • Hepatotoxicity (Hepatic toxicity)

Anadrol is a carbon-17-alpha alkylated compound. This modification prevents the drug from being deactivated in the liver, which allows a very high percentage of the steroid to enter the bloodstream after oral administration.

17-alpha alkylated anabolic/androgenic steroids can be hepatotoxic. Prolonged or high doses may cause liver damage. In rare cases, life-threatening liver dysfunction can develop. Periodic medical monitoring during each cycle for liver enzyme monitoring is recommended.

The administration of 17-alpha alkylated steroids is usually limited to 6-8 weeks in an attempt to avoid inflammation of the liver.

  • Cardiovascular Side Effects

Anabolic/androgenic steroids can have harmful effects on cholesterol. This translates into a decrease in HDL (good) cholesterol and an increase in LDL (bad) cholesterol, which can shift the balance from HDL to LDL, favoring a higher risk of atherosclerosis.

The relative effect of anabolic/androgenic steroids on serum lipids depends on:

  • The dose
    • route of administration (oral / injection,)
    • type of steroid (flavored or non-flavoring)
    •level of resistance to liver metabolism.

Anabolic/androgenic steroids can also adversely affect blood pressure and triglycerides. They can reduce endothelial relaxation, cause left ventricular hypertrophy, or generally potentially increase the risk of cardiovascular disease and myocardial infarction.

To help reduce cardiovascular fatigue, it is advisable to maintain a cardio workout program. Also, you should reduce the intake of saturated fat, cholesterol, and simple carbohydrates at all times during the course of AAS administration. You should supplement your diet with fish oil and natural cholesterol such as Lipid Stabil or a product with similar ingredients.

Testosterone Suppression

All anabolic/androgenic steroids, when taken at doses sufficient to promote muscle growth, suppress endogenous testosterone production. Testosterone is the major male androgen and produces strong negative feedback on endogenous testosterone production.

Testosterone-based medicines similarly have a strong effect on the hypothalamus and the regulation of natural hormones. After stopping the injection of testosterone stimulants, the natural levels of testosterone in the body will restore within 1-4 months.

Keep in mind that after discontinuing Anadrol, the side effects are so powerful that they are compared to those on the cycle. It starts with the fact that the level of water retention rapidly decreases and the athlete dramatically loses his body weight.

This can occur but should not be a cause for concern. Recovery of endogenous testosterone production with an appropriate program remains paramount. Just after the end of the intake, some athletes choose to inject Deca-Durabolin for several weeks. This is done in order to “solidify the new mass” and can be an effective practice, at least from a psychological point of view.

Intake & Dosages of Anadrol

The dose for amateur athletes is 50mg oxymetholone per day. You should divide  the daily dose into two or three parts. You should always take the tablets with food and liquid such as water and tea.

The dose for bodybuilders is from 50mg to 150mg.  Keep in mind that when taking 3 tablets (3x50mg), the liver processes approximately the equivalent of 30 tablets of Dianabol.

If you are taking it for the first time, start with one 50 mg tablet, increasing the dose no sooner than a week later – one tablet in the morning and one evening with food and liquid.

To reduce side effects, we recommend dividing the dose and taking it several times a day.

Most commonly, athletes combine Anadrol with Anavar, Parabolan, Deca-Durabolin, and Primobolan. However, if you are more susceptible to side effects, it is preferable to use it separately.

A popular practice after stopping it is to continue with testosterone Enanthate or Sustanon250. Among professionals, it is very popular in combination with Parabolan and Sustanon500. Newcomers should not do it, however.

Final Thoughts

As you can clearly see, the side effects of Anadrol are significantly higher in number when you compare them to the benefits. Clearly, the only benefit is a significant increase in muscle mass and strength for a short period of time.

This is useful for professional bodybuilders but practically pointless for any other people. You will literally look much bigger for about two or three months and suddenly shrink back to your old size. Not only that, but you will experience side effects for sure.

Therefore, is it really worth it? If you still feel like you want to try this steroid, I suggest trying its legal alternative instead – Anadrole. It is a much safer option for you and you will experience practically the same results. However, you should always consult with your physician before you try any of these substances.

About the Author

Merrick Beslear is's resident testosterone, male health and body building expert, he has been a personal trainer for over 13 years and has studied Kinesiology at Penn State University. Merrick has a passion in health supplements and how they have the ability to change not only one's physical appearance, but also mental abilities and health.