Deca Durabolin Review – Uses, Side Effects, Dosages

By Merrick Beslear | Legal Steroids

Sep 08

Nandrolone, known also as Deca Durabolin, is a synthetic anabolic steroid.  It is characterized as an injectable anabolic steroid with a strong anabolic effect and weak androgenic properties.

These qualities make it an excellent steroid for increasing muscle mass and increasing strength. The main advantages which make Nandrolone such a popular steroid are two:

  • It works well for most people regardless of gender, age, and weight
  • It is low in liver toxicity

None of the potential benefits change the fact that Deca Durabolin is, in fact, an illegal substance. Luckily, there is a new legal alternative that you can purchase instead – Decaduro. Similar to other approved steroid alternatives, it is a much safer option and has identical results. If you wish to start a cycle with Deca Durabolin, you should consider getting Decaduro instead.



What is Deca Durabolin? Science of Deca Durabolin:

Deca-Durabolin is the trade name of Nandrolone Decanoate, the injectable form of the anabolic steroid Nandrolone. The decanoate ester provides a slow release of Nandrolone from the injection spot for up to 3 weeks. The ratio between androgen and anabolic action is 37:125.

Nandrolone is very close to testosterone in structure, with the only difference being the lack of a carbon atom at the 19th position.

Like testosterone, Nandrolone has relatively strong anabolic properties. In contrast, usually, people associate it with less androgenic manifestations. This is due to its reduction to the weaker steroid dihydronandrolone in the same tissues. This is due to the higher metabolite of testosterone, dihydrotestosterone.

The soft action of Deca-Durabolin makes it one of the most popular injectable steroids in the world. It is often also a recommended choice because it is non-toxic to the liver. It significantly increases strength and lean muscle mass and has no strong androgenic or estrogenic side effects.

It is manufactured by the pharmaceutical giant Organon. It has a variety of uses in medicine.

  • For pre- and postoperative accumulation of muscle mass
  • For the treatment of osteoporosis and advanced breast cancer
  • For painful loss of muscle mass
  • For geriatric conditions associated with general weakness,
  • For burns, severe traumas, ulcers
  • As adjunctive therapy in some forms of anemia and selectively in some cases of growth retardation and development in children

Nandrolone decanoate provides a sharp peak in the release of Nandrolone in the blood 24-48 hours after deep muscle injection, with levels beginning to decrease steadily until it reaches a concentration close to baseline about 2 weeks after injection. With this delayed-release, the effective life of Nandrolone decanoate is 8 days.

Nandrolone has little affinity for estrogen conversion, which is only about 20% of that of testosterone. This is due to the fact that while in the liver, Nandrolone is converted to Estradiol, in other more active tissues with respect to steroid aromatization, such as adipose tissue, Nandrolone has little or no aroma.

Accordingly, estrogenic side effects are much lower than with testosterone. However, higher dose of Deca-Durabolin may lead to increased estrogen levels and such side effects as increased water retention, adipose tissue, and gynecomastia.

When they occur, I recommend that you use antiestrogens such as Clomiphene citrate and Tamoxifen citrate or an aromatase inhibitor such as Arimidex (Anastrazole) to control estrogen levels more effectively. The problem with it, however, is the price and the negative effect on blood lipid levels.

Nandrolone has a certain tendency to bind to progesterone receptors, so it can cause some estrogen-like side effects such as inhibiting the natural production of testosterone and enhancing adipose tissue deposition, including the appearance of gynecomastia. Because it inhibits the natural production of testosterone, when combined with another androgen, a decrease in libido in men can occur.

Deca Durabolin – Effects, Properties, and Usage

Aromatase does not affect Deca Durabolin, it also doesn’t aromatize. However, it does turn into estrogen, but in very small amounts: five times less than testosterone. At the same time, Deca is known to exhibit progestogenic activity, which at doses above 600 mg. a week can lead to gynecomastia.

Deca Durabolin, like testosterone, stimulates and activates satellite cells and increases IGF-1 in the blood, leading to muscle hyperplasia.

Even at low doses, Nandrolone retains water in the body not as much as testosterone but still has slight water retention. While preparing for competition, the use of Nandrolone decanoate is not appropriate.

The use of Deca Durabolin has a beneficial effect on the joints. This fact is not attributed to “the accumulation of water in joint capsules as a result of the use of nandrolone,” and as a consequence, facilitates the functioning of the joints. In fact, this is not true. More precisely, not everything. That is to say, no water in the joints accumulates under the influence of nandrolone.

In clinical practice, Nandrolone has a lot of uses: in the treatment of malnutrition, for recovery from injury, surgery, heart attacks. In women, it increases the level of hemoglobin in the blood, reduces the loss of calcium from the bones. Not only athletes use it as an anabolic drug. Ballet dancers, circus artists, theater and movie stars – also occasionally take it.

However, Deca Durabolin is illegal in the United States and in many countries worldwide. It continuously loses its popularity in Europe as well. If you wish to start a cycle with it, I would suggest purchasing Decaduro instead.

Decaduro is the only legal alternative for Deca Durabolin and is also available in the U.S.

Side Effects of Deca Durabolin

While there are benefits and professionals consider Deca Durabolin as one of the safest anabolic steroids, this is certainly not the safest option on the market. There are side effects, and some of them can be extremely annoying.

Estrogenic side effects

Nandrolone has a low tendency to convert to estrogen, only about 20% compared to observations with testosterone use. This is because in the liver, nandrolone decanoate is converted to estradiol, but in other more fragrant sites such as nandrolone adipose tissue is much more susceptible to the aromatization process. With the use of nandrolone decanoate (Deca Durabolin), the estrogen-related side effects create far less concern than with the use of testosterone

Increased levels of estrogen may nevertheless be associated with higher doses of intake, which may cause undesirable side effects such as increased water and fat retention, gynecomastia, and others. Administration of antiestrogens such as clomiphene citrate or tamoxifen citrate may be required to prevent the occurrence of estrogenic side effects.

An athlete may take turns using an aromatase inhibitor such as Arimidex (anastrozole), which more effectively controls estrogen by preventing its synthesis. However, aromatase inhibitors can be quite expensive compared to antiestrogens and can also have a negative effect on blood lipids.

It should also be noted that nandrolone decanoate (Deca Durabolin) exhibits progestin activity in the body. Although progesterone is a c-19 based steroid, the removal of this group creates a hormone with a greater binding affinity to its corresponding receptor.

Because of this feature, anabolic steroids without the c-19 group are shown to have an affinity for the progesterone receptor. Progesterone-related side effects are similar to those of estrogen, including negative feedback in inhibiting testosterone production and increased fat retention. Progestins also increase the stimulating effect of estrogens on mammary gland growth.


Once classified as an anabolic steroid, the occurrence of androgenic side effects with the use of nandrolone decanoate (Deca Durabolin) is possible, especially at high-dose injections. They are expressed in oily skin, acne, facial and body hair.

Men with a genetic predisposition to hair loss (androgenic alopecia) may notice rapid balding. Women should be aware of the potential virilizing effects of anabolic-androgenic steroids. These include changes in voice tone, menstrual disorders, and changes in skin structure, facial hair and enlargement of the clitoris.

Nandrolone decanoate (Deca Durabolin) is a steroid with relatively low androgenic activity compared to testosterone, Methandrostenolone (fluoxymesterone) or fluoxymesterone and exhibits significantly lower androgenic side effects.

Due to its mild androgenic nature and its ability to suppress the endogenous production of testosterone, nandrolone decanoate (Deca Durabolin) tends to interfere with men’s libido when not used in conjunction with another androgen.


Anabolic/androgenic steroids can have harmful effects on serum cholesterol. This includes a tendency to lower HDL (good) cholesterol and increase LDL (bad) cholesterol, which can shift the balance from HDL to LDL, which may increase the risk of atherosclerosis.

The effect of steroids of this type depends on the dose, route of administration (oral / injection,) type of steroid (flavored or non-flavoring) and level of resistance to liver metabolism.

Studies show that by taking 600 mg of Nandrolone decanoate (Deca Durabolin) per week for 10 weeks, HDL cholesterol levels decrease by 26%. This suppression is slightly greater than that measured with the same dose of testosterone enanthate. There was also a slightly greater negative effect on the HDL / LDL ratio with the use of Nandrolone decanoate (Deca Durabolin) compared to testosterone cypionate (testosterone cypionate).

Testosterone Suppression

All anabolic/androgenic steroids are most likely going to suppress your endogenous testosterone production. Studies show that an injection of 100 mg per week of nandrolone decanoate (Deca Durabolin) for 6 weeks results in an approximately 57% decrease in serum testosterone levels.

At a dose of 300 mg per week, this drop reaches 70%. The progestational activity of nandrolone decanoate (Deca Durabolin) is thought to significantly contribute to the suppression of testosterone synthesis during administration, despite the low tendency to become estrogen.

What to Take After a Cycle with Deca Durabolin

Your testosterone production can become a problem with Deca, especially after long cycles. For this, you can use ancillary drugs such as Nolvadex and Proviron at the end of the cycle.

An estrogen antagonist such as Nolvadex or Clomid is often administered within a few weeks. Both formulations provide good levels of testosterone stimulation, although it may take several weeks to get the best effect.

You can add HCG injections as additional security. It will quickly restore the normal ability of the testicles to respond to the restarted gonadotropin. For this purpose, 2500-5000 units can be injected every 5 days. Then, the antagonist should be left alone for a few more weeks to stabilize testosterone production. Deca remains active for a long time and therefore, anti-estrogens will not be as effective while the steroid is still in the blood.


Effective doses of nandrolone start at 200 mg and up weekly. Based on the sufficiently long half-life of nandrolone decanoate, Deca Durabolin can be injected once every 7-8 days.

However, people rarely use it alone. The classic combination is Deca with Methane (Methandienone) – because these two steroids are synergistic.

Do not use Deca Durabolin with other progestogens (Trenbolone, Anadrol). The negative effects of such combinations are permanent.

Normally, athletes inject it once a week. Optimal doses range between 200mg. and 600mg. from a practical point of view. If you use it in combination with other steroids, you should take 400mg. at most.

Once you start, you should observe your results in a few weeks. Nandrolone decanoate half-life is performed over a period of 6-7 days. The drug leaves metabolites in the body for up to 18 months, and this is important to know when using a steroid doping test.


In the combination of Deca with Winstrol during the months/weeks prior to a race, for example, it has been seen as strongly enhancing the type and musculature and definition. A strong non-aromatizing androgen such as Parabolan can also be added, providing increased firmness and muscle density.

As an acceptable anabolic, Deca can also be added to mass cycles. The Deca and Dianabol classics have been a staple for decades and always provide excellent muscle growth. A stronger androgen such as Anadrol or Testosterone may also be a substitute for better results.

Final Thoughts

Although, professionals consider Deca Durabolin as relatively safe, it continues to be illegal in most countries. When you compare it to other similar substances, it truly seems like the better choice.

However, it does have a lot of potential side effects just as every other steroid. Whether you use it or not, it is entirely up to you. Nevertheless, if you decide to start a cycle and want to purchase it, I suggest a safer alternative – Decaduro.

Always choose the healthier option, if we can call any steroid healthy. In addition, you can hardly find Deca Durabolin for sale legally.

About the Author

Merrick Beslear is's resident testosterone, male health and body building expert, he has been a personal trainer for over 13 years and has studied Kinesiology at Penn State University. Merrick has a passion in health supplements and how they have the ability to change not only one's physical appearance, but also mental abilities and health.

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